Hosting is still an issue since it requires mod_perl to run properly, but I've found Apache::ASP to be awesome after having used CGI, ColdFusion, and servlets/JSP. I say just colocate a server and use what's best for you if you can't find a host with the right stuff.
The big advantage that most people aren't mentioning much is speed of *development*! You can always throw more hardware at it if you find execution speed to really be an issue (I never have...mod_perl is plenty zippy for me). Hardware is cheap; programming effort is not. I am a Sun Certified Java programmer, but I can do the same things I can do in Java in Perl with probably 1/3 of the code. I've reached the point where the only reason I care about Java is for my resume. Perl is the language for getting things done!
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