There are situations (like a mod_perl CGI under rapid fire) where you need every bit of speed you can get.
After profiling you may find that the performance you are looking for cannot be achieved using your setup. More memory, changing the Apache/mod_perl configuration, a faster processor, more processors, or not doing the bottleneck in Perl (if that's where the bottleneck is) are some of the ways to help you get there.
It might be but a loop or subroutine that's part of a (much) larger project, so "don't use perl if you need speed" is quite an ignorant advice.
Just to make sure: that advice wasn't given.
antichef asked us what's faster in Perl, he didn't ask whether Perl was fastest in the first place...
Assuming he has a performance problem (and not just some theoretical curiosity), maybe he should have. Besides, one form could be rewritten to the other by the optimizer in another Perl version, so what's the point?
— Arien