We connect to 3 DB platforms (all on MySQL tho).
One is a single master, the other 2 are masters with several slaves.
I don't pass dbh's around between methods, since sometimes I may have connected to a slave for read-only operations, but might have passed the the dbh into a method requiring write access to the master, so it's easier to connect in each method (to the relevant master/slave), plus, it's MySQL, so not a massive hit on the connection time.
We clearly connect/disconnect a fair amount, but this isn't causing performance implications (yet).
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