my @strings = (
    'nnxx.yy2 = 234 abc',
    'foo bar = 39 baz *',
    ....
);

my $pattern = join '|',
    map { my $s = quotemeta; $s =~ s/(=\s*)\d+/$1\\d+/g; $s } @strings;

my $qr = qr/^($pattern)$/;

while (<>) {
    print if /$qr/;
}