I don't see how you exclude those matches with a regex, unless you concat all 10,000+ strings together with pipe symbols, and I doubt a regex like that would be very efficient.
One solution:
Regexp::AssembleIt creates an optimized regex that checks all your strings at once. It is usually shorter and much faster than your "pipe"d regex. For example, 10,000 strings of each 5 characters were turned into a regex less than 25,000 characters long.
CountZero
A program should be light and agile, its subroutines connected like a string of pearls. The spirit and intent of the program should be retained throughout. There should be neither too little or too much, neither needless loops nor useless variables, neither lack of structure nor overwhelming rigidity." - The Tao of Programming, 4.1 - Geoffrey James
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